home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9603.zip
/
M9630140.TXT
< prev
next >
Wrap
Text File
|
1996-02-27
|
3KB
|
41 lines
Document 0140
DOCN M9630140
TI Cytomegalovirus viraemia in HIV infection: association with intercurrent
infection.
DT 9603
AU Evans MR; Booth JC; Wansbrough-Jones MH; Division of Infectious
Diseases, St George's Hospital Medical; School, London, U.K.
SO J Infect. 1995 Jul;31(1):21-6. Unique Identifier : AIDSLINE MED/96019120
AB The aim of this retrospective study was to investigate the clinical
significance of cytomegalovirus (CMV) viraemia in HIV-infected subjects
(with or without AIDS) who had attended this hospital during a 45 month
period. They were reviewed regularly and, when clinically indicated,
tested for CMV viraemia. The blood of 105 subjects was cultured for CMV
and 34 had at least one episode of CMV viraemia during the review
period. The viraemia was present during CMV disease in nine of the 34
positive patients and was the only detectable infection in another two.
In the remaining 23 patients, CMV viraemia occurred in association with
intercurrent opportunistic infection. Among these 23 patients, the
viraemia resolved in 12 after treatment (or natural resolution) of the
intercurrent infection and only one of these 12 developed CMV disease
(mean review period: 8 months). In another seven patients, CMV viraemia
persisted despite treatment (or natural resolution) of the intercurrent
infection and four subsequently developed CMV disease (mean review
period: 4 months) (P = 0.08, Fisher's exact test). From the remaining
four patients, no specimens for CMV culture were obtained after
treatment of the intercurrent infection. The CD4 count was higher in the
12 patients in whom there was resolution of the viraemia [mean CD4 60 x
10(6)/l] compared with the seven in whom the viraemia persisted [mean
CD4 45 x 10(6)/l]. These findings suggest that in some HIV-positive
patients, CMV viraemia was potentiated by intercurrent infection with
another micro-organism and that its treatment was sufficient to mitigate
the CMV disease.
DE AIDS-Related Opportunistic Infections/*COMPLICATIONS Comparative Study
Cytomegalovirus Infections/*COMPLICATIONS Human HIV
Infections/*COMPLICATIONS Retrospective Studies Time Factors
Viremia/*COMPLICATIONS Virology/METHODS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).